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Updated: Nov 14, 2025

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
Published on: December 16, 2021
Immune activation kickstarts the gut microbiota.
1Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Gastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA.
This study reveals how the gut microbiota adapts to intestinal immune activation. Researchers used gnotobiotic mice and multi-omics to understand commensal responses to acute inflammation, uncovering key microbial adaptations.
Area of Science:
- Microbiology
- Immunology
- Gastroenterology
Background:
- The gut microbiota plays a crucial role in regulating intestinal immunity.
- The reciprocal effects of immune activation on gut commensals remain largely unexplored.
Purpose of the Study:
- To investigate how gut commensals respond and adapt to acute immune activation.
- To elucidate the impact of intestinal immunity on the gut microbial community.
Main Methods:
- Utilized a reductionist approach with gnotobiotic mouse models.
- Employed multi-omics analyses (genomics, transcriptomics, metabolomics) to study microbial changes.
- Induced acute immune activation in the host.
Main Results:
- Demonstrated specific adaptive responses of gut commensals to immune challenges.
- Identified key microbial pathways and genes involved in adaptation.
- Showcased the dynamic interplay between the host immune system and commensal bacteria.
Conclusions:
- Gut commensals exhibit adaptive strategies in response to acute intestinal immune activation.
- This research provides novel insights into host-microbe interactions during inflammation.
- Understanding these adaptations is critical for developing targeted microbiome-based therapies.
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