Targeting Stem Cells in Chronic Inflammatory Diseases
Mari van de Vyver1, Yigael S L Powrie2,3, Carine Smith3
1Department of Medicine, Faculty of Medicine & Health Sciences, Stellenbosch University, Cape Town, South Africa. vandevyverm@sun.ac.za.
Advances in Experimental Medicine and Biology
|March 16, 2021
Summary
Mesenchymal stem cell (MSC) dysfunction worsens type 2 diabetes. Rejuvenating MSCs with anti-inflammatory agents, antioxidants, or biological therapies shows promise for improving healing and quality of life in diabetic patients.
Area of Science:
- Gerontology
- Immunology
- Regenerative Medicine
Background:
- Mesenchymal stem cell (MSC) dysfunction is linked to aging and type 2 diabetes.
- Inflammation and oxidative stress cause cellular senescence, impairing MSC immunomodulatory and regenerative functions, worsening disease severity and comorbidities.
Purpose of the Study:
- To review MSC dysregulation in diabetes mellitus.
- To explore intervention strategies for MSC rejuvenation and functional restoration.
Main Methods:
- Literature review focusing on therapeutic interventions for MSC dysfunction.
- Discussion of pharmacological (NFκB antagonists), natural (phytomedicine), and biological (exosomes, probiotics) agents.
- Consideration of methodological challenges for in vivo applications.
Main Results:
- In vitro studies indicate anti-inflammatory agents, antioxidants, and biological agents can revitalize MSCs.
- These interventions hold potential for improving MSC function in the context of diabetes.
Conclusions:
- Targeting stem/progenitor cells to restore function can improve healing outcomes and quality of life for diabetic patients.
- An integrated systems approach and understanding of disease pathology are crucial for identifying effective in vivo therapeutic candidates.
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