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Updated: Nov 12, 2025

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition
Published on: February 8, 2018
Timing isn't everything: opposing roles for perisomatic inhibition.
Adam P Caccavano1, Chris J McBain1
1Laboratory of Cellular and Synaptic Physiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Parvalbumin (PV) interneurons time brain activity, while cholecystokinin (CCK) interneurons have distinct, yet unknown, behavioral roles. A new mouse model reveals these different functions during behavior.
Area of Science:
- Neuroscience
- Cellular Neuroscience
- Behavioral Neuroscience
Background:
- Perisomatic inhibition is crucial for neural timing.
- Parvalbumin-containing (PV) interneurons mediate this inhibition.
- The function of cholecystokinin-containing (CCK) interneurons remains poorly understood.
Purpose of the Study:
- To investigate the distinct roles of PV and CCK interneurons in behavior.
- To elucidate the specific contributions of these interneuron populations to neural circuits.
Main Methods:
- Development of a novel mouse model.
- Behavioral analysis in mice.
- Electrophysiological recordings (implied).
Main Results:
- PV and CCK interneurons exhibit fundamentally distinct behavioral roles.
- Demonstration of differential contributions to behavior by these neuronal subpopulations.
Conclusions:
- PV and CCK interneurons play non-overlapping roles in regulating behavior.
- Understanding these distinct roles is key to comprehending neural circuit function.
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