Related Experiment Video
Updated: Nov 12, 2025
07:22
Author Spotlight: Optimizing iPSC Differentiation for Efficient Production to Generate Kidney Organoids
Published on: September 1, 2023
3.1K
Stem/progenitor cell in kidney: characteristics, homing, coordination, and maintenance
Jiewu Huang1, Yaozhong Kong2, Chao Xie2
1State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Ave, Guangzhou, 510515, China.
Stem Cell Research & Therapy
|March 21, 2021
Summary
Stem/progenitor cells offer promising kidney repair, but understanding their characteristics and homing is crucial. This review explores kidney stem cells and microenvironments for improved regenerative therapies.
Area of Science:
- Nephrology
- Regenerative Medicine
- Cell Biology
Background:
- Renal failure is a global health issue with limited treatment options.
- Current renal replacement therapies have significant complications.
- Stem/progenitor cell therapy presents a potential solution for kidney repair.
Purpose of the Study:
- To review stem/progenitor cells in kidney regeneration.
- To understand kidney-specific microenvironments and stem cell interactions.
- To identify strategies for enhancing stem cell therapy efficacy.
Main Methods:
- Literature review of stem/progenitor cells in kidney research.
- Analysis of kidney-specific microenvironment factors.
- Discussion of stem cell homing and therapeutic strategies.
Main Results:
- Identified key stem/progenitor cell sources (kidney in situ, bone marrow).
- Elaborated on the kidney microenvironment's role in stem cell behavior.
- Highlighted strategies to improve stem cell therapy outcomes.
Conclusions:
- Understanding stem/progenitor cell characteristics and kidney microenvironment is vital.
- Optimizing stem cell homing and interaction can advance kidney protection strategies.
- This review provides insights for developing novel stem cell-based kidney therapies.
Related Concept Videos
01:19Multipotency of Hematopoietic Stem Cells
3.5K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.5K
01:26Stem Cell Niche
5.7K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.7K
01:21Hematopoiesis
7.6K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
7.6K
01:14Maintenance of the ES Cell State
2.4K
The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
2.4K
01:01Regulation of Hematopoietic Stem Cells
3.6K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.6K
01:21Lineage Commitment
3.6K
Commitment is the process whereby stem cells:
3.6K