Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

43
Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
43
Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

61
Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
61
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

89
Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
89
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

6.2K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
6.2K
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

327
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
327
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

367
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
367

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of laparoscopy in the management of abdominal trauma.

Journal of visceral surgery·2026
Same author

A progeria syndrome links DNA hypermethylation to age-related pathology.

Nature genetics·2026
Same author

ACTH-dependent Cushing's syndrome in MEN1: When multiple tumors complicate the diagnosis.

Annales d'endocrinologie·2026
Same author

Predicting Best Performers After Minimally Invasive Left Pancreatectomy: Insights From a National Cohort.

Annals of surgery·2026
Same author

Ambulatory thyroidectomy: A paradigm shift in surgical safety and patient-centered care.

Journal of visceral surgery·2026
Same author

Salivary and lacrimal disorders in patients treated with radioiodine for differentiated thyroid cancer.

European thyroid journal·2026
Same journal

Obesity-related thyroid reflections: from weight gain to weight loss.

European thyroid journal·2026
Same journal

Triiodothyroacetic acid exerts tissue-specific thyromimetic effects without tachycardia and hyperthermia in male mice.

European thyroid journal·2026
Same journal

Single-cell RNA sequencing: a powerful tool to study heterogeneity in papillary and anaplastic thyroid carcinoma.

European thyroid journal·2026
Same journal

Estimation of the delay for resumption of breastfeeding after 131-iodine therapy by milk radioactivity measurement.

European thyroid journal·2026
Same journal

Optimizing Frozen Section Sampling for Thyroid Follicular Neoplasms through Intraoperative Ultrasound Guidance.

European thyroid journal·2026
Same journal

The Effect of Iodinated Contrast Media on Thyroid (Dys)function in Children.

European thyroid journal·2026
See all related articles

Related Experiment Video

Updated: Nov 11, 2025

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

19.9K

Therapeutic Plasma Exchange in Refractory Hyperthyroidism.

Clotilde Saïe1, Cécile Ghander1, Samir Saheb2

  • 1Thyroid and Endocrine Tumors Unit, Pitié-Salpêtrière Hospital APHP, Sorbonne University, Paris, France.

European Thyroid Journal
|March 29, 2021
PubMed
Summary
This summary is machine-generated.

Therapeutic plasma exchange (TPE) safely reduced thyroid hormone levels by approximately 50% in patients with refractory hyperthyroidism. TPE is a viable option when medical treatments fail or are contraindicated, regardless of thyrotoxicosis cause.

Keywords:
HyperthyroidismIodine-induced thyrotoxicosisTherapeutic plasma exchangeThyroid surgeryThyrotoxicosis

More Related Videos

An Ex vivo Culture System to Study Thyroid Development
08:33

An Ex vivo Culture System to Study Thyroid Development

Published on: June 6, 2014

11.9K
An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug
07:50

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

Published on: June 4, 2021

2.9K

Related Experiment Videos

Last Updated: Nov 11, 2025

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

19.9K
An Ex vivo Culture System to Study Thyroid Development
08:33

An Ex vivo Culture System to Study Thyroid Development

Published on: June 6, 2014

11.9K
An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug
07:50

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

Published on: June 4, 2021

2.9K

Area of Science:

  • Endocrinology
  • Internal Medicine
  • Nephrology (for TPE procedure)

Background:

  • Refractory hyperthyroidism poses a significant clinical challenge.
  • Medical treatments are often insufficient or contraindicated for severe cases.

Purpose of the Study:

  • To evaluate the efficacy and safety of therapeutic plasma exchange (TPE) in managing hyperthyroid patients.
  • To assess patient outcomes following TPE treatment for thyrotoxicosis.

Main Methods:

  • Retrospective review of 22 patients with refractory thyrotoxicosis (Graves' disease, amiodarone-induced thyrotoxicosis, etc.) treated with TPE.
  • Analysis of thyroid hormone levels (fT4, fT3) before and after TPE.
  • Documentation of complications, subsequent treatments, and clinical outcomes.

Main Results:

  • TPE significantly decreased free T4 by 48% and free T3 by 52% (p<0.001).
  • No complications occurred during 91 TPE sessions; 16/22 patients underwent successful thyroidectomy.
  • TPE provided clinical improvement in amiodarone-induced thyrotoxicosis, allowing continued amiodarone use in one case.

Conclusions:

  • Therapeutic plasma exchange offers a safe and effective method to rapidly reduce thyroid hormone levels in refractory hyperthyroidism.
  • TPE should be considered for patients unresponsive to or intolerant of standard medical therapies, irrespective of thyrotoxicosis etiology.