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Isomers of 10-hydroxynortriptyline in geriatric depression
1Department of Psychiatry, New York Hospital-Cornell Medical Center, White Plains 10605.
Therapeutic Drug Monitoring
|January 1, 1988
Abstract:
In geriatric, depressed inpatients treated with nortriptyline (NT), total unconjugated plasma concentrations of the Z isomer of the 10-hydroxylated metabolite (10-OH-NT) were determined simultaneously with concentrations of the E isomer by high-performance liquid chromatography. Z-10-OH-NT concentrations averaged 14% of E-10-OH-NT concentrations.