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PREVALENCE OF HYPERURICEMIA IN PATIENTS WITH CHRONIC HEART FAILURE
Q Sanikidze1, I Mamacashvili2, Sh Petriashvili1
11Aleksandre Aladashvili Clinic, Georgia.
Georgian Medical News
|April 5, 2021
Summary
Hyperuricemia (HU) is common in heart failure (HF) patients and linked to worse outcomes. Early detection of HU in HF patients is crucial for better management and preventing complications.
Area of Science:
- Cardiology
- Nephrology
- Internal Medicine
Background:
- Heart failure (HF) is a complex clinical syndrome.
- Hyperuricemia (HU), characterized by elevated serum uric acid levels, is increasingly recognized as a potential comorbidity in HF.
- The clinical significance and prevalence of HU in HF patients warrant further investigation.
Purpose of the Study:
- To determine the prevalence of hyperuricemia in patients diagnosed with heart failure.
- To investigate the clinical importance and associations of hyperuricemia in this patient cohort.
Main Methods:
- A cohort of 126 heart failure patients was studied, divided into a main group with HF and HU (75 patients) and a control group with HF but without HU (51 patients).
- Standardized clinical evaluations, including physical examination, NYHA class, and laboratory tests (serum uric acid, creatinine, ferritin), were performed.
- Exercise capacity was assessed using the 6-min walk test, and echocardiographic parameters (LVEF, LV mass index, IVS) were analyzed.
Main Results:
- Patients with HU exhibited a higher prevalence of diabetes mellitus compared to those without HU.
- Significantly lower left ventricular ejection fraction (LVEF) was observed in patients with HU (38.2±7.0%) versus those without (44.5±5.1%).
- Patients with HU showed significantly thicker interventricular septum (IVS) and a larger left ventricular (LV) mass index, indicating adverse cardiac remodeling.
Conclusions:
- Hyperuricemia is highly prevalent in patients with chronic heart failure and is independently associated with reduced exercise capacity.
- Factors such as female gender, higher NYHA class, low LVEF, hyperuricemia, and lower eGFR predict diminished exercise capacity.
- Routine assessment of uric acid levels in all chronic heart failure patients is recommended for improved clinical management and prevention of complications.
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