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Whispering-gallery microlasers for cell tagging and barcoding: the prospects for in vivo biosensing
Nikita Toropov1, Frank Vollmer2
1Department of Physics and Astronomy, Living Systems Institute, University of Exeter, Exeter, EX4 4QD, UK. n.toropov@exeter.ac.uk.
Light, Science & Applications
|April 15, 2021
Summary
Researchers developed biointegrated low-threshold whispering-gallery-mode (WGM) lasers for single-cell tracking. These miniature WGM lasers offer unique spectral features for in vivo sensing applications.
Area of Science:
- Optics and Photonics
- Biomedical Engineering
- Micro-optics
Background:
- Whispering-gallery-mode (WGM) microresonators are explored for novel laser applications.
- Development of low-threshold WGM lasers is crucial for miniaturization and efficiency.
- Biointegration of WGM lasers enables advanced biological sensing capabilities.
Discussion:
- The proposed biointegrated WGM lasers demonstrate potential for large-scale parallel single-cell tracking.
- The narrow spectral features of miniature WGM lasers are key to their sensing capabilities.
- Recent advancements bridge the gap between model applications and in vivo functionalities.
Key Insights:
- Miniature WGM lasers can be biointegrated for advanced biological applications.
- Low-threshold WGM lasers enable efficient single-cell analysis.
- Unique spectral properties of WGM lasers are harnessed for in vivo tags and sensors.
Outlook:
- Future research will focus on in vivo deployment of WGM laser-based tags and sensors.
- Further development aims to enhance the scale and precision of single-cell tracking.
- Exploration of diverse biological applications leveraging WGM laser technology is anticipated.
