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Constricted Apertures for Dynamic Trapping and Micro-/Nanoscale Discrimination Based on Recapture Kinetics
Vinay Sharma1, Kevin J Freedman1
1University of California-Riverside, Department of Bioengineering, 900 University Avenue, Riverside, California 92521, United States.
Nano Letters
|April 16, 2021
Summary
This study explores using rapid directional switching of hydrodynamic forces for advanced metrology. Multipass measurements enable cell discrimination, dynamic trapping, and discrete interval sensing for micro/nanoscale structures.
Area of Science:
- Biophysics
- Nanotechnology
- Analytical Chemistry
Background:
- Analyte sensing through constricted apertures is a robust technology used broadly.
- Micro/nanoscale structures typically use electrophoretic force to translocate through pores.
Purpose of the Study:
- To explore advances in metrology using rapid directional switching of hydrodynamic forces.
- To investigate cell discrimination phenomena achieved through multipass measurements.
- To examine features of hydrodynamic focusing, including dynamic trapping and discrete interval sensing.
Main Methods:
- Utilizing rapid directional switching of hydrodynamic forces for metrology.
- Performing multipass measurements of microscale and nanoscale structures.
- Analyzing hydrodynamic focusing phenomena.
Main Results:
- Demonstrated advances in metrology through hydrodynamic force manipulation.
- Achieved cell discrimination using multipass measurements.
- Observed dynamic trapping and discrete interval sensing capabilities.
Conclusions:
- Hydrodynamic force switching offers advanced metrology capabilities for micro/nanoscale analysis.
- Multipass measurements are effective for discriminating between different cell types.
- Hydrodynamic focusing presents versatile features for sensing applications.
