Related Experiment Video

Updated: Nov 8, 2025

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

7.0K

Notch Signalling: A Potential Therapeutic Pathway in Oral Squamous Cell Carcinoma

Ankit Pandey1, Sreeshma Bhuvanadas1, Joel P Joseph1

  • 1Department of Genetic Engineering, School of Bioengineering, College of Engineering and Technology, SRM Institute of Science and Technology, Potheri, Kattankulathur, Chengalpattu District, Tamilnadu 603203,India.

Endocrine, Metabolic & Immune Disorders Drug Targets
|April 22, 2021
PubMed

Insights

The Notch signalling pathway drives cancer progression and metastasis, particularly in oral squamous cell carcinoma (OSCC). Understanding this pathway is crucial for developing targeted cancer therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signalling

Background:

  • Cancer involves abnormal cell growth due to altered gene expression, leading to systemic failure.
  • The Notch signalling pathway is frequently dysregulated in various cancers, promoting cell proliferation, survival, and angiogenesis.
  • Oral squamous cell carcinoma (OSCC) is a major oral cancer subtype where aberrant Notch signalling contributes to tumor progression and metastasis.

Purpose of the Study:

  • To review the Notch signalling pathway, its components, and its forms.
  • To elucidate the role of Notch signalling in the progression and metastasis of oral squamous cell carcinoma (OSCC).

Main Methods:

  • Literature review of Notch signalling pathway.
  • Analysis of Notch pathway's role in oral squamous cell carcinoma (OSCC) progression and metastasis.

Main Results:

  • Notch signalling components are upregulated in numerous cancers.
  • Aberrant Notch signalling is implicated in the progression and metastasis of oral squamous cell carcinoma (OSCC).

Conclusions:

  • The Notch signalling pathway is a key player in oral squamous cell carcinoma (OSCC) development.
  • Targeting the Notch pathway may offer therapeutic strategies for OSCC.
Keywords:
Cancercellular dysfunction.metastasisnotch signalling pathwayoral squamous cell carcinomatumour progression

More Related Videos

Stimulation of Notch Signaling in Mouse Osteoclast Precursors08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

8.1K
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

11.8K

Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.7K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.2K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.8K
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
9.5K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
7.9K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.8K