Related Experiment Video
Updated: Nov 8, 2025
09:24
Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease
Published on: April 17, 2017
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Cough augmentation techniques for people with chronic neuromuscular disorders
Brenda Morrow1, Andrew Argent2, Marco Zampoli3
1Department of Paediatrics, University of Cape Town, Cape Town, South Africa.
The Cochrane Database of Systematic Reviews
|April 22, 2021
Summary
Cough augmentation techniques may improve peak cough flow in neuromuscular disorders, but evidence on safety and efficacy is very uncertain. More research is needed to confirm benefits for respiratory health and quality of life.
Area of Science:
- Respiratory Medicine
- Neurology
- Rehabilitation
Background:
- Neuromuscular disorders often cause weak coughs, increasing risk of respiratory complications.
- Cough augmentation techniques aim to enhance mucus clearance and reduce respiratory infections.
Purpose of the Study:
- To evaluate the efficacy and safety of cough augmentation techniques.
- Focus on adults and children with chronic neuromuscular disorders.
Main Methods:
- Systematic review of randomized controlled trials (RCTs), quasi-RCTs, and cross-over trials.
- Searched multiple databases including Cochrane, MEDLINE, Embase, CINAHL, and ClinicalTrials.gov.
- Assessed trial eligibility, data extraction, and risk of bias; used GRADE for evidence certainty.
Main Results:
- 11 studies with 287 participants (ages 3-73) were included.
- Limited analyses due to study reporting issues; primary outcomes (hospitalizations, adverse events) were not reported.
- Techniques may increase peak cough flow, but evidence is very uncertain; no significant differences found between alternative techniques.
Conclusions:
- Very uncertain about the safety and efficacy of cough augmentation techniques.
- Insufficient evidence on effects on gaseous exchange, pulmonary function, or quality of life.
- Further research is essential to establish the role of these interventions.
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