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Related Concept Videos

Protein and Protein Structure02:15

Protein and Protein Structure

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Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
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In multi-pass transmembrane proteins, the polypeptide chain crosses the membrane more than once. The transmembrane polypeptide chain either forms an α-helix or β-strand structure. α-Helix containing multi-pass transmembrane proteins are ubiquitous, whereas β-strand containing ones are mainly found in gram-negative bacteria, mitochondria, and chloroplasts.
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Protein Organization01:13

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Protein Organization01:24

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Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
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Protein Folding01:25

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Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
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Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
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Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

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Exploring the structure-function relationship in a hypothetical membrane protein from a nucleotide sequence.

Manuel I Osorio1,2, Dino G Salinas1

  • 1Centro de Investigación Biomédica, Facultad de Medicina, Universidad Diego Portales, Santiago, Chile.

Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology
|April 29, 2021
PubMed
Summary
This summary is machine-generated.

This educational activity uses free online tools for proteomic analysis to predict protein structure and function from nucleotide sequences. It is ideal for introductory courses on the protein structure-function relationship.

Keywords:
bioinformaticsprotein structureundergraduate

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Area of Science:

  • Biochemistry
  • Bioinformatics
  • Molecular Biology

Background:

  • Understanding the protein structure-function relationship is fundamental in molecular biology.
  • Educational tools are needed to effectively teach these concepts in introductory courses.

Purpose of the Study:

  • To present an educational activity for estimating protein structure and function.
  • To utilize freely available bioinformatics software and databases for this estimation.

Main Methods:

  • The activity involves using internet-based software for proteomic analysis.
  • Input is a coding nucleotide sequence of a hypothetical protein.
  • Output includes estimations of protein structure and function.

Main Results:

  • The proposed activity successfully demonstrates the estimation of protein structure and function.
  • It leverages accessible, free online resources for practical learning.

Conclusions:

  • This bioinformatics activity provides a practical approach to teaching protein structure-function relationships.
  • It is suitable for integrated introductory science courses.