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Bilayer Scaffolds for Interface Tissue Engineering and Regenerative Medicine: A Systematic Reviews
Sheida Hashemi1, Leila Mohammadi Amirabad2,3, Fatemeh Dehghani Nazhvani4
1School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Advances in Experimental Medicine and Biology
|May 1, 2021
Summary
Bilayer scaffolds show promise for regenerating multilayered tissues like bone and skin. Combining these scaffolds with mesenchymal stem cells and differentiation media enhances tissue regeneration, particularly for osteochondral defects.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Bilayer scaffolds are advanced structures for engineering complex, multilayered tissues.
- Their application spans various regenerative medicine fields, including vascular, osteochondral, skin, nerve, and urinary bladder tissues.
Purpose of the Study:
- To systematically review the application and efficacy of bilayer scaffolds in multilayered tissue engineering.
- To provide a concise literature review of different bilayer scaffold types and their performance.
Main Methods:
- A systematic literature search was conducted in PMC, NCBI, and PubMed (April 2008–December 2019) following PRISMA guidelines.
- Included studies were animal-based, focusing on bilayer scaffolds for osteochondral, bone, skin, neural, urinary bladder, or vascular tissues, excluding in vitro-only studies.
Main Results:
- Thirty-five full-text articles met the criteria, with 15 in soft tissue engineering and 20 in hard tissue engineering.
- Optimal multilayered tissue regeneration was observed when bilayer scaffolds were combined with mesenchymal stem cells and differentiation media prior to implantation.
- Collagen and PLGA were the most common biomaterials used in bilayer scaffolds, particularly for osteochondral tissue engineering.
Conclusions:
- Bilayer scaffolds, when appropriately designed and combined with specific stem cells, significantly improve multilayer tissue regeneration.
- This review offers guidance for researchers and surgeons in designing bilayer scaffolds for targeted tissue regeneration.
- Further research can optimize bilayer scaffold design for specific tissue targets and stem cell combinations.
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