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Updated: Nov 7, 2025

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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Synthesis and Properties of 4'-ThioLNA/BNA

Rion Maeda1, Noriko Saito-Tarashima2, Hideaki Wakamatsu1

  • 1Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Komatsushima 4-4-1, Aoba-ku, Sendai 981-8558, Japan.

Organic Letters
|May 3, 2021
PubMed
Summary

Researchers developed a novel 4'-thio analogue of locked nucleic acid/bicyclic nucleic acid (LNA/BNA) monomers for oligonucleotide therapeutics. This new thio-LNA/BNA monomer was successfully synthesized and incorporated into oligonucleotides.

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