IMPROVEMENT OF TREATMENT OF COMPLICATED FORMS OF DIABETIC FOOT SYNDROME

Considering an increasing the incidence of diabetes mellitus, the aim of the study was to improve the results of treatment of patients with diabetic foot syndrome due to the proposed complex VAC-associated therapy. The use of this method within 5 days of treatment was increased the local blood flow of the wounds from 26-31 to 49-53 mm Hg (p<0.01), while in the comparison group the blood flow was at the level of 32-37 mm Hg. The granulation tissue in the wound developed on average by 4.76±0.82 days, which is significantly faster than in the control group - 9.88±1.13 (p<0.05). Wound contamination of the main group was 7.9±0.26 Lg CFU/g tissue for treatment, on the 5th day - 2.8±0.23 Lg CFU/g tissue, and the regenerative-inflammatory type of cytograms prevailed in smears-prints. On the 10th day - there was no pathological microflora in the wound, marginal epithelialization appeared, a cytogram of the regenerative type. At the same time, in the comparison group, the contamination before treatment was 7.7±0.19 Lg CFU/g (p<0.05), and on the 5th and 10th days the indicators were significantly higher - 6.1±0.18 Lg CFU/g (p<0.01) and 3.2±0.17 Lg CFU/g (p<0.01), respectively, and the cytograms still remained of the inflammatory type. Due to the improvement of microcirculation, rapid cleaning of the wound and a decrease in local signs of inflammation, stimulation of the growth of granulation tissue, microbial decontamination and a significant reduction in the time for cleaning and healing the wound, the proposed method of combined VAC-therapy can significantly reduce the time required to prepare the wound for its healing. The proposed complex method of VAC-therapy significantly improves the healing processes of wounds and shortens the treatment time for complications of diabetes mellitus.