CORRELATION OF CD4+Т LYMPHOCYTES ACTIVATION WITH INTERLEUKIN IL-9, IL-17, IL- 22 PROFILES IN THE PERIPHERAL BLOOD OF...

Area of Science:

• Immunology
• Dermatology
• Cell Biology

Background:

• Psoriasis is a T cell-mediated chronic inflammatory skin disease.
• The IL-23/Th17 immune axis is central to psoriasis pathogenesis.
• Th1, Th17, Th22, and Th9 cells are implicated in psoriasis inflammation and memory.

Purpose of the Study:

• To evaluate T cell profiles and the IL-23/Th17 axis in moderate to severe plaque psoriasis.
• To assess levels of IL-17A, IL-22, and IL-9 in peripheral blood of psoriasis patients.
• To analyze the expression of the T helper cell activation marker CD69.

Main Methods:

• Compared peripheral blood from psoriasis patients (n=18) with healthy controls (n=15).
• Measured IL-17A, IL-22, and IL-9 levels using flow cytometry (FACScan).
• Assessed CD69 expression on T helper cells.

Main Results:

• Reduced CD4+ T cell expression and decreased CD69 activation marker expression in psoriasis patients.
• Significantly increased IL-22 levels observed in psoriasis patients.
• Decreased IL-9 and IL-17 levels in peripheral blood Th cells of psoriasis patients.

Conclusions:

• Peripheral blood T cell profiles and IL-23/Th17 axis activity differ significantly in psoriasis patients compared to controls.
• Lower IL-9 and IL-17 in peripheral blood suggest their mobilization to psoriatic skin lesions.
• These findings highlight altered immune cell dynamics in psoriasis pathogenesis.