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Updated: Nov 6, 2025

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance
Published on: February 14, 2025
Oxygen-Sensing Paramagnetic Probes for Clinical Oximetry
M M Kmiec1, D Tse1, Periannan Kuppusamy2
1Department of Radiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Abstract:
Electron paramagnetic resonance (EPR) oximetry based on lithium naphthalocyanine paramagnetic crystals as oxygen sensors enables direct measurement of the partial pressure of oxygen (pO2) in tissues. The method uses topical or implantable forms of these oxygen-sensing crystals embedded in a biocompatible siloxane elastomer. This article presents a summary of these sensors for EPR oximetry and their applicability for tissue oxygen measurement in the clinic.
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