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Immune-Based Therapy for COVID-19
Abdolreza Esmaeilzadeh1,2, Davood Jafari3,4, Safa Tahmasebi5
1Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. a46reza@zums.ac.ir.
Advances in Experimental Medicine and Biology
|May 11, 2021
Summary
Understanding the immune response to SARS-CoV-2 is crucial for developing effective COVID-19 treatments. This review explores various immune-based therapies, including antibody and cell-based approaches, to combat the virus.
Area of Science:
- Immunology
- Virology
- Infectious Diseases
Background:
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a novel zoonotic disease with significant global health implications.
- The lack of approved drugs necessitates exploration of immune-based treatment strategies.
- Understanding COVID-19 immunopathology and immune responses to SARS-CoV-2 is vital.
Purpose of the Study:
- To provide insights into immune-based treatments for COVID-19.
- To analyze the immunopathology of COVID-19 and immune responses to SARS-CoV-2.
- To discuss strategies for inhibiting viral infection, improving immune response, and regulating hyperactivated immunity.
Main Methods:
- Review of existing literature on immunopathology and immune responses to SARS-CoV-2.
- Discussion of various immune-based therapeutic approaches.
- Categorization of treatments based on their mechanism of action.
Main Results:
- Several immune-based therapies show promise for COVID-19 treatment.
- Antibody-based therapies include convalescent plasma, IVIG, monoclonal, and polyclonal antibodies.
- Other approaches include cell-based treatments, vaccines, cytokine therapies, JAK inhibitors, and more.
Conclusions:
- Immune-based treatments offer a promising avenue for managing COVID-19.
- Targeting viral mechanisms and modulating immune responses are key therapeutic strategies.
- Further research and clinical trials are needed to validate these approaches.
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