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Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality
Published on: April 7, 2023
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Insights on the Critical Parameters Affecting the Probiotic Viability During Stabilization Process and Formulation
Sharda Gurram1, Durgesh K Jha1, Devanshi S Shah1
1Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, 400019, India.
AAPS Pharmscitech
|May 19, 2021
Summary
Probiotic formulations aim to deliver live microorganisms for health benefits. This review highlights critical processing factors affecting probiotic viability to ensure therapeutic efficacy.
Area of Science:
- Microbiology
- Pharmaceutical Sciences
- Nutraceuticals
Background:
- Probiotics, live microorganisms, offer health benefits for various conditions, including gut disorders and inflammation.
- Effective probiotic therapy requires delivering a sufficient number of viable microorganisms, typically 10^8-10^9 CFU/g.
- Probiotic viability is compromised by environmental and processing factors during formulation.
Purpose of the Study:
- To review critical process parameters impacting probiotic viability during stabilization and formulation.
- To emphasize the importance of understanding these factors for effective probiotic delivery.
Main Methods:
- Literature review focusing on factors affecting probiotic viability in formulations.
- Analysis of processing parameters such as temperature, humidity, and pressure.
Main Results:
- Probiotic bacteria are sensitive to environmental and processing conditions, reducing viability.
- Specific parameters like temperature and humidity significantly impact bacterial survival.
Conclusions:
- Understanding and controlling critical process parameters are essential for maintaining probiotic viability.
- Optimized formulation development ensures the delivery of efficacious doses of probiotics for therapeutic effects.
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