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Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:

Inflammatory Bowel Disease II: Crohn's Disease

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...

Irritable Bowel Syndrome III: Medical and Nursing Management

Irritable Bowel Syndrome III: Medical and Nursing Management

Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.

Chronic Bowel Disorders: Introduction

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

Inflammatory Bowel Disease I: Ulcerative Colitis

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...

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Updated: Nov 4, 2025

Postoperative Ileus Murine Model

Postoperative Ileus Murine Model

Published on: July 12, 2024

Post-infection Irritable Bowel Syndrome.

Antonio Berumen¹, Adam L Edwinson¹, Madhusudan Grover²

¹Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA.

Gastroenterology Clinics of North America

|May 24, 2021

Summary

Acute gastrointestinal infections significantly increase the risk of developing irritable bowel syndrome (IBS), particularly in younger women after severe bacterial or protozoal enterocolitis. Mechanisms involve microbiome changes, immune activation, and altered gut physiology.

Keywords:

Bacteria Barrier function Diarrhea Gut-brain axis Infectious gastroenteritis Inflammation Microbiome

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Murine Ileocolic Bowel Resection with Primary Anastomosis

Murine Ileocolic Bowel Resection with Primary Anastomosis

Published on: October 29, 2014

Area of Science:

Gastroenterology
Infectious Diseases
Immunology

Background:

Acute gastrointestinal infections are a major risk factor for irritable bowel syndrome (IBS).
Post-infectious IBS (PI-IBS) is more common after bacterial and protozoal infections than viral ones.
Younger individuals, women, and those experiencing severe enterocolitis face a higher risk of developing PI-IBS.

Purpose of the Study:

To review the epidemiologic evidence linking gastrointestinal infections to IBS development.
To explore the underlying pathophysiological mechanisms of PI-IBS.
To identify factors influencing the risk and development of PI-IBS.

Main Methods:

Review of epidemiologic data on IBS risk factors.
Analysis of proposed disease mechanisms in human and animal models.
Identification of luminal and physiological alterations contributing to PI-IBS symptoms.

Main Results:

Severe enterocolitis, particularly bacterial and protozoal, increases PI-IBS risk.
Key mechanisms include microbiome disruption, epithelial/neuronal changes, and immune responses.
Altered gut permeability, transit, and visceral hypersensitivity mediate PI-IBS symptoms.

Conclusions:

Acute gastrointestinal infections are a significant trigger for IBS.
PI-IBS development involves complex interactions between the microbiome, immune system, and gut physiology.
Understanding these mechanisms is crucial for developing targeted therapies for PI-IBS.