Related Experiment Video
Updated: Nov 4, 2025
14:04
Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents
Published on: March 25, 2016
15.6K
Panuveitis Presumed Secondary to Ibrutinib Therapy
Ophthalmic Surgery, Lasers & Imaging Retina
|May 26, 2021
Summary
Ibrutinib therapy, used for chronic lymphocytic leukemia, may cause panuveitis, a severe eye inflammation. This condition can be treated with local steroids without stopping cancer treatment.
Area of Science:
- Ophthalmology
- Oncology
- Pharmacology
Background:
- Secondary uveitis is a known complication of ibrutinib therapy.
- Panuveitis has not been previously reported with ibrutinib use.
- Ibrutinib is a targeted therapy for chronic lymphocytic leukemia.
Observation:
- A case of asymmetric, bilateral panuveitis is described in a patient undergoing ibrutinib therapy.
- The patient had chronic lymphocytic leukemia.
Findings:
- Panuveitis is a potential, albeit rare, side effect of ibrutinib treatment.
- Local steroid therapy was effective in managing the panuveitis.
Implications:
- Ophthalmologists should consider panuveitis in patients on ibrutinib presenting with uveitis.
- Treatment with local steroids allows for continuation of essential cancer therapy.
Related Concept Videos
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
299
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
299
01:29Drugs for Treatment of Ulcerative Colitis in IBD
284
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
284
01:26Pulmonary Tuberculosis IV
251
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
251
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
99
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
99
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
274
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
274
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
265
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
265