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Emerging Preclinical and Clinical Applications of Theranostics for Nononcological Disorders
Majid Assadi1, Narges Jokar1, Anna Yordanova2
1Department of Molecular Imaging and Radionuclide Therapy (MIRT), The Persian Gulf Nuclear Medicine Research Center, Bushehr Medical University Hospital, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
Abstract:
Studies in nuclear medicine have shed light on molecular imaging and therapeutic approaches for oncological and nononcological conditions. Using the same radiopharmaceuticals for diagnosis and therapeutics of malignancies, the theranostics approach, has improved clinical management of patients. Theranostic approaches for nononcological conditions are recognized as emerging topics of research. This review focuses on preclinical and clinical studies of nononcological disorders that include theranostic strategies. Theranostic approaches are demonstrated as possible in the clinical management of infections and inflammations. There is an emerging need for randomized trials to specify the factors affecting validity and efficacy of theranostic approaches in nononcological diseases.
Insights
Theranostics, using radiopharmaceuticals for both diagnosis and therapy, shows promise for non-oncological conditions like infections and inflammation. Further clinical trials are needed to confirm its effectiveness and validity in these emerging applications.
Area of Science:
- Nuclear Medicine
- Molecular Imaging
- Radiopharmaceuticals
Background:
- Nuclear medicine advances offer molecular imaging and therapeutic strategies.
- Theranostics, utilizing radiopharmaceuticals for diagnosis and therapy, enhances oncological patient care.
- Theranostic applications for non-oncological conditions are an emerging research area.
Purpose of the Study:
- To review preclinical and clinical studies on theranostic strategies for non-oncological disorders.
- To highlight the potential of theranostics in managing infections and inflammations.
- To identify the need for further research, including randomized trials.
Main Methods:
- Review of preclinical and clinical studies.
- Focus on theranostic approaches in non-oncological conditions.
- Analysis of existing literature on infections and inflammations.
Main Results:
- Theranostic approaches are feasible for managing infections and inflammations.
- Evidence suggests potential benefits in non-oncological disease management.
- The review consolidates current understanding of theranostics in non-oncological settings.
Conclusions:
- Theranostics holds promise for non-oncological conditions, particularly infections and inflammations.
- There is a clear need for rigorous randomized trials to establish efficacy and validity.
- Further research is essential to optimize theranostic strategies for broader clinical use.
