[Advances in metabolic engineering for vitamins production]

Area of Science:

• Biotechnology
• Metabolic Engineering
• Microbial Synthesis

Background:

• Vitamins are essential organic compounds vital for life activities.
• Dietary intake or synthesis is necessary as the body cannot produce sufficient vitamins.
• Growing global demand fuels applications in medicine, food, feed, and cosmetics.

Purpose of the Study:

• To review 30 years of metabolic engineering advances in vitamin production.
• To focus on microbial synthesis of water-soluble and lipid-soluble vitamins.
• To discuss challenges and future directions in fermentative vitamin production.

Main Methods:

• Review of metabolic engineering strategies for vitamin biosynthesis.
• Analysis of microbial fermentation processes for vitamin production.
• Exploration of synthetic biotechnology for strain improvement.

Main Results:

• Significant progress in metabolic engineering for producing various vitamins.
• Microbial synthesis offers a sustainable, safe, and energy-efficient alternative to chemical methods.
• Identification of bottlenecks in current fermentative vitamin production.

Conclusions:

• Metabolic engineering has revolutionized vitamin production via microbial routes.
• Future research should focus on synthetic biotechnology for next-generation vitamin-producing strains.
• Microbial synthesis presents a greener and safer approach to meet the increasing demand for vitamins.