Bioorthogonal nanozymes: progress towards therapeutic applications
Xianzhi Zhang1, Rui Huang1, Sanjana Gopalakrishnan1
1Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA.
Trends in Chemistry
|June 7, 2021
Summary
Bioorthogonal nanozymes are synthetic nanocatalysts that create molecules for imaging and therapy within living systems. Researchers are developing smart nanodevices with tunable catalytic activity for advanced diagnostics and treatments.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Synthetic Chemistry
Background:
- Bioorthogonal nanocatalysts, or nanozymes, offer novel ways to generate molecules for medical applications.
- These synthetic systems perform chemical transformations not found in natural cellular processes.
Purpose of the Study:
- To review strategies for fabricating bioorthogonal nanocatalysts.
- To explore their potential in diagnostic and therapeutic applications.
Main Methods:
- Fabrication of nanozymes using synthetic chemistry approaches.
- Modulation of catalytic activity via structural, chemical, and physical signals.
Main Results:
- Nanozymes can be engineered for specific bioorthogonal reactions.
- Development of smart nanodevices with controllable catalytic functions.
Conclusions:
- Bioorthogonal nanozymes represent a versatile platform for in vivo molecular generation.
- These nanocatalysts hold significant promise for future diagnostic and therapeutic innovations.
