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Updated: Nov 2, 2025

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
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Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

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Differentiated Cells Derived from Hematopoietic Stem Cells and Their Applications in Translational Medicine

Sophia S Fernandes1, Lalita S Limaye1, Vaijayanti P Kale2

  • 1Stem Cell Lab, National Centre for Cell Science, Pune, India.

Advances in Experimental Medicine and Biology
|June 11, 2021
PubMed

Hematopoietic stem cells (HSCs) and their development are one of the most widely studied model systems in mammals. In adults, HSCs are predominantly found in the bone marrow, from where they maintain homeostasis. Besides bone marrow and mobilized peripheral blood, cord blood is also being used as an alternate allogenic source of transplantable HSCs. HSCs from both autologous and allogenic sources are being applied for the treatment of various conditions like blood cancers, anemia, etc. HSCs can further differentiate to mature blood cells. Differentiation process of HSCs is being extensively studied so as to obtain a large number of pure populations of various differentiated cells in vitro so that they can be taken up for clinical trials. The ability to generate sufficient quantity of clinical-grade specialized blood cells in vitro would take the field of hematology a step ahead in translational medicine.

Keywords:
Clinical utilityHSCs in therapeuticsHematopoietic stem cells (HSCs)Mature blood cells

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