Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

7.1K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.1K
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

301
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
301
Esophagus01:24

Esophagus

1.7K
The esophagus, a muscular conduit linking the pharynx and stomach, measures roughly 10 inches (25.4 cm) and sits behind the trachea. It remains collapsed when not swallowing. The esophagus follows a predominantly straight path through the thoracic mediastinum and enters the abdominal cavity through a diaphragmatic opening known as the esophageal hiatus.
The movement of edibles from the pharynx into the esophagus is facilitated by the upper esophageal sphincter, which is formed primarily by the...
1.7K
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

381
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
381
Tumor Progression02:07

Tumor Progression

6.7K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Textbook outcome can be reached in the learning curve for hybrid robot-assisted esophagectomy-experience from a German high-volume center.

Journal of robotic surgery·2026
Same author

Treatment strategies for Boerhaave syndrome: multinational retrospective cohort study.

The British journal of surgery·2025
Same author

Simultaneous cholecystectomy during esophagectomy: A systematic review and meta-analysis on gallstone formation and subsequent cholecystectomy rates.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2025
Same author

Application of artificial intelligence in esophageal surgery: a systematic review.

Journal of robotic surgery·2025
Same author

Comparison of Pretreatment Strategies for cT2cN0 Staged Adenocarcinoma of the Esophagus and the Gastroesophageal Junction: A European High-Volume Center Cohort Analysis.

Annals of surgical oncology·2025
Same author

A New Type of Ward for Perioperative Care in Visceral Surgery: Initial Experience in a High-Volume Center.

Deutsches Arzteblatt international·2025
Same journal

Mammalian Respiratory Chain Complex Assemblies and Their Links to Mitochondria Stress-Induced Human Diseases.

Advances in experimental medicine and biology·2026
Same journal

Enzyme Assemblies in Nucleotide Metabolism: Structure, Regulation, and Disease Implications.

Advances in experimental medicine and biology·2026
Same journal

The Pyruvate Dehydrogenase Complex: A 90-Year-Old Enigma Shaping the Future of Structural Enzymology.

Advances in experimental medicine and biology·2026
Same journal

Regulation of the Anti-termination RNA Transcription Complex by Lon-Mediated Lambda N Degradation.

Advances in experimental medicine and biology·2026
Same journal

PCNA Macromolecular Complexes: PCNA Serves as a Molecular Hub Regulating Multiple Cellular Processes Inside and Outside of the Nucleus.

Advances in experimental medicine and biology·2026
Same journal

Dynamic Assemblies in Genome Maintenance.

Advances in experimental medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Oct 31, 2025

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

3.6K

Esophageal Tumor Microenvironment.

Henrik Nienhüser1, Naita Wirsik1, Thomas Schmidt2

  • 1Department of General, Viceral, Cancer and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany.

Advances in Experimental Medicine and Biology
|June 29, 2021
PubMed
Summary
This summary is machine-generated.

The tumor microenvironment, including inflammatory cytokines and stem cells, offers new therapeutic targets for esophageal cancer. Research explores these elements and anti-angiogenic therapies to improve patient survival beyond surgery.

Keywords:
AngiogenesisBarrett esophagusCancer cell linesClinical trialsEsophageal cancerFibroblastsInterleukin-1Interleukin-6MacrophagesMouse modelsPericytesPreclinical modelsStem cellsTranslational researchTumor microenvironment

More Related Videos

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion
10:42

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion

Published on: July 6, 2022

4.0K
Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

589

Related Experiment Videos

Last Updated: Oct 31, 2025

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

3.6K
Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion
10:42

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion

Published on: July 6, 2022

4.0K
Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

589

Area of Science:

  • Oncology
  • Cancer Biology
  • Immunology

Background:

  • Esophageal cancer treatment options are limited, with disappointing survival rates.
  • Surgical resection is the only curative approach, necessitating novel medical therapies.
  • The tumor microenvironment presents a promising target for innovative esophageal cancer treatments.

Purpose of the Study:

  • To review in vitro, preclinical, and translational research on the tumor microenvironment in esophageal cancer.
  • To discuss the role of inflammatory cytokines, stem cells, and angiogenesis in esophageal cancer development and treatment.
  • To summarize current clinical trials targeting the tumor microenvironment.

Main Methods:

  • Review of in vitro data and preclinical animal studies.
  • Analysis of translational research findings.
  • Overview of current clinical trials.

Main Results:

  • Interleukin overexpression is linked to Barrett lesions and reduced survival in esophageal cancer.
  • Stem cells play a significant role in esophageal carcinoma development.
  • Angiogenesis and anti-angiogenic therapies are critical factors in esophageal cancer.

Conclusions:

  • The tumor microenvironment offers multiple targets for esophageal cancer therapy.
  • Further research into inflammatory cytokines, stem cells, and angiogenesis is crucial.
  • Clinical trials investigating tumor microenvironment-targeted therapies are ongoing.