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Updated: Oct 31, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Using experience-based co-design with patients, carers and healthcare professionals to develop theory-based
Beth Fylan1, Justine Tomlinson2, David K Raynor3
1School of Pharmacy and Medical Sciences, University of Bradford, Richmond Road, Bradford, BD7 1DP, UK; NIHR Yorkshire and Humber Patient Safety Translational Research Centre. Bradford Institute for Health Research, Temple Bank House, Bradford, BD9 6RJ, UK.
Experience-Based Co-Design (EBCD) is a participatory method adapted for developing complex healthcare interventions. This research shows how EBCD integrates with theory and research for multi-site studies, improving healthcare quality.
Area of Science:
- Healthcare Research
- Participatory Design
- Intervention Development
Background:
- Experience-Based Co-Design (EBCD) is a participatory method for healthcare quality improvement.
- Traditionally, EBCD has been applied within single services or settings.
- EBCD focuses on the experiences of patients and healthcare providers.
Purpose of the Study:
- To present the adaptation of EBCD for developing complex, theory-based interventions for multi-site research.
- To outline how EBCD can be integrated into intervention development and evaluation studies.
- To suggest methods for appraising interventions for multi-site feasibility.
Main Methods:
- Outlining co-design and EBCD stages.
- Detailing adaptations, research tools, and methods for integrating EBCD into research.
- Combining EBCD with behavior change theories and methods.
Main Results:
- Demonstrated integration of EBCD into research projects.
- Showcased assimilation of research approaches into EBCD stages.
- Identified potential for using behavior change theories within EBCD.
Conclusions:
- EBCD is a collaborative approach centralizing patients and staff in healthcare improvement.
- EBCD can be effectively integrated into research projects for intervention development.
- Behavior change theories enhance understanding of EBCD intervention mechanisms.
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