Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Nano-radiosensitizers targeting tumor radioresistance: mechanisms, rational design, and clinical prospects.

Chemical communications (Cambridge, England)·2026

Same author

DNAzyme-Enhanced CRISPR/Cas12a Cascade Enables Isothermal, One-Pot RNA Diagnostics.

ACS applied materials & interfaces·2026

Same author

DHA/Fe<sup>2+</sup>-doped porphyrin COFs enable ROS-amplified multimodal tumor therapy.

Chemical communications (Cambridge, England)·2026

Same author

Framework Doping Enhances COF-DNA Nanoplatforms for Dual RNA Imaging and Phototherapy.

Analytical chemistry·2026

Same author

A dual-strike strategy against glycolytic and mitochondrial metabolism for potentiated mild photothermal therapy.

Chemical communications (Cambridge, England)·2026

Same author

Dual-Cascade Activated DNAzyme Nanoreactor within a Zn-Based MOF for Mitochondrial Gene Regulation.

ACS applied materials & interfaces·2025

Search research articles

Related Experiment Video

Updated: Oct 31, 2025

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time

Published on: August 26, 2009

Delivery nanoplatforms based on dynamic covalent chemistry.

Fei Lu¹, Huiwen Zhang¹, Wei Pan¹

¹College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China. lina@sdnu.edu.cn tangb@sdnu.edu.cn.

Chemical Communications (Cambridge, England)

|July 1, 2021

Summary

Dynamic covalent chemistry nanoplatforms offer adaptive and responsive drug delivery. This review highlights their progress, challenges, and future potential for enhanced therapeutic performance.

More Related Videos

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Published on: November 25, 2015

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Published on: August 11, 2018

Related Experiment Videos

Last Updated: Oct 31, 2025

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time

Published on: August 26, 2009

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Published on: November 25, 2015

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Published on: August 11, 2018

Area of Science:

Materials Science
Nanotechnology
Chemistry

Background:

Nanoplatforms are crucial for drug and biologic delivery.
Dynamic covalent chemistry (DCC) offers unique properties like adaptiveness and stimuli-responsiveness.
These properties are vital for overcoming drug delivery challenges.

Purpose of the Study:

To summarize recent advancements in DCC-based nanoplatforms.
To discuss the improved delivery efficiency and therapeutic outcomes.
To identify current challenges and future perspectives in the field.

Main Methods:

Literature review of recent progress in DCC nanoplatforms.
Analysis of key features: adaptiveness, stimuli-responsiveness, specificity, reversibility, and feasibility.
Discussion of challenges and future outlook.

Main Results:

DCC nanoplatforms demonstrate significant improvements in drug delivery efficiency.
Enhanced therapeutic performance is achieved through tailored nanoplatform design.
Key features of DCC enable precise control over drug release and targeting.

Conclusions:

DCC-based nanoplatforms represent a promising strategy for advanced drug delivery.
Further research is needed to address existing challenges and unlock full potential.
This field offers a valuable platform for developing next-generation therapeutics.