A Rare Case of Primary Breast Osteosarcoma Evaluated with Multiple Modalities

Area of Science:

• Oncology
• Radiology
• Pathology

Background:

• Primary breast osteosarcoma (PBO) is an exceptionally rare malignant tumor.
• This report details a unique case of PBO in a female patient.

Purpose of the Study:

• To present a case of PBO evaluated using multiple imaging modalities.
• To discuss the diagnostic challenges and features of PBO.

Main Methods:

• Case presentation of a woman in her 70s with a right breast mass.
• Utilized mammography, ultrasound, MRI, PET-CT, and CT for evaluation.
• Histopathological examination following mastectomy for definitive diagnosis.

Main Results:

• Imaging revealed a lobulated mass with coarse calcification, strong MRI enhancement, and high diffusion-weighted signal.
• PET-CT showed high 18F-fluorodeoxyglucose uptake.
• Histology confirmed PBO with periosteal formation, calcification, and pleomorphic stromal cells.

Conclusions:

• PBO diagnosis requires consideration in cases of calcified breast tumors with aggressive growth.
• Multimodality imaging plays a crucial role in the preoperative assessment of PBO.
• Early and accurate diagnosis is vital for appropriate patient management.