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Emerging Therapies for Alcoholic Hepatitis.
Ma Ai Thanda Han1, Nikolaos Pyrsopoulos2
1Division of Gastroenterology and Hepatology, Rutgers New Jersey Medical School, 185 South Orange Avenue, H-526, Newark, NJ 07103, USA.
Clinics in Liver Disease
|July 7, 2021
Summary
Alcoholic hepatitis incidence is rising, demanding new treatments beyond corticosteroids. This review explores innovative therapies targeting key disease pathways and ongoing clinical trials for alcoholic hepatitis.
Area of Science:
- Hepatology
- Gastroenterology
- Pharmacology
Background:
- Increasing incidence and high mortality rates of alcoholic hepatitis necessitate improved therapeutic strategies.
- Current corticosteroid therapy for severe alcoholic hepatitis offers limited benefits and marginal response rates.
- There is a critical need for novel, safe, and effective treatments for alcoholic hepatitis.
Purpose of the Study:
- To review emerging therapies for alcoholic hepatitis targeting diverse pathogenetic mechanisms.
- To provide an overview of ongoing clinical trials investigating new alcoholic hepatitis treatments.
Main Methods:
- Literature review of novel therapeutic targets in alcoholic hepatitis.
- Analysis of ongoing clinical trials for alcoholic hepatitis management.
Main Results:
- Novel therapies target the gut-liver axis, inflammatory cascade, oxidative stress, and hepatic regeneration.
- Several clinical trials are underway to evaluate new treatment modalities for alcoholic hepatitis.
Conclusions:
- Emerging therapies show promise for addressing unmet needs in alcoholic hepatitis treatment.
- Further research and clinical trials are essential to develop effective interventions for alcoholic hepatitis.
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