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The Impact of Uric Acid and Hyperuricemia on Cardiovascular and Renal Systems

Davide Agnoletti1, Arrigo F G Cicero2, Claudio Borghi2

  • 1Internal Medicine Department, IRCCS Sacro Cuore Hospital, Viale Luigi Rizzardi 4, Negrar di Valpolicella (VR) 37024, Italy.

Cardiology Clinics
|July 12, 2021
PubMed

Insights

Uric acid

Area of Science:

  • Biochemistry
  • Clinical Medicine
  • Cardiovascular Research

Background:

  • Gout has a 5000-year history, with uric acid implicated in its pathogenesis.
  • Uric acid's role in oxidative stress, inflammation, and organ outcomes is extensively studied.
  • Hyperuricemia management involves lifestyle changes and targeted therapies.

Purpose of the Study:

  • To review the implications of uric acid in health and disease.
  • To assess the efficacy of uric acid-lowering therapies on clinical outcomes.
  • To highlight the need for further research on uric acid's cardiovascular effects.

Main Methods:

  • Literature review of basic and clinical studies on uric acid.
  • Analysis of data regarding uric acid-lowering therapy in hyperuricemia.
  • Evaluation of evidence on cardiovascular and renal outcomes related to uric acid.

Main Results:

  • Uric acid-lowering therapy did not improve hard outcomes in asymptomatic hyperuricemia.
  • Therapy is reserved for symptomatic hyperuricemia.
  • Dietary and lifestyle modifications are crucial for hyperuricemia management.

Conclusions:

  • Current evidence does not support uric acid-lowering drugs for asymptomatic hyperuricemia.
  • Symptomatic hyperuricemia warrants therapeutic intervention.
  • Further investigation into the cardiovascular impact of uric acid-lowering drugs is necessary.

Keywords:
Cardiovascular riskHyperuricemiaInflammationOxidative stressUric acid

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