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Updated: Oct 29, 2025

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Biomolecular Detection employing the Interferometric Reflectance Imaging Sensor IRIS
Published on: May 3, 2011
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AIE + ESIPT activity-based NIR Cu2+ sensor with dye participated binding strategy
Jie Jiang1, Haifeng Sun1, Yanlei Hu1
1School of Chemistry and Chemical Engineering, Key Laboratory of the Colloid and Interface Chemistry, Ministry of Education, Shandong University, Jinan 250100, China. jiejiang@sdu.edu.cn.
Abstract:
A novel activity-based Cu2+ fluorescent probe featuring multidentate binding sites was synthesized. It functions through chelation with Cu2+, which in turn specifically triggers hydrolysis of the probe to release a near-infrared emission with AIE + ESIPT properties. The probe was found to be capable of ratiometric imaging of Cu2+ in living HeLa cells.

