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Thalamic Deep Brain Stimulation Is Effective in Alleviating Craniocervical Dystonia

Virgilio Gerald H Evidente1, Pnina Rokhlin1, Maris H Evidente1

  • 1Movement Disorder Center of Arizona Scottsdale Arizona USA.

Movement Disorders Clinical Practice
|July 26, 2021
PubMed
Summary

No abstract available in PubMed .

Keywords:
DBSMeige syndromeblepharospasmcraniocervical dystoniadeep brain stimulationthalamic DBS

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Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
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