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Laser-Activated Corneal Adhesive: Retinal Safety in Rabbit Model
Jackie Tan1, Leslie John Ray Foster1,2, Frank James Lovicu1
1The University of Sydney, Save Sight Institute, Discipline of Ophthalmology, Sydney Medical School, Sydney, New South Wales, Australia.
Translational Vision Science & Technology
|July 28, 2021
Summary
Laser activation of corneal adhesive showed no retinal damage in rabbits. Higher laser power or prolonged exposure can cause retinal necrosis, but the clinical application is safe.
Area of Science:
- Ophthalmology
- Biomedical Engineering
- Retinal Science
Background:
- Corneal incisions require effective sealing methods.
- Laser-activated adhesives offer a novel approach to wound closure.
- Potential retinal effects of laser activation require thorough investigation.
Purpose of the Study:
- To evaluate laser irradiation's impact on retinal tissue during corneal adhesive activation.
- To determine if the laser process causes observable retinal changes, both visually and microscopically.
- To assess the safety of laser-activated corneal adhesives for ophthalmic applications.
Main Methods:
- Pigmented Dutch Belted rabbits underwent fundus assessment before laser treatment.
- A near-infrared laser (125 mW, 45 seconds) activated corneal adhesive in 18 eyes.
- Control groups received higher power/duration laser exposure; retinal assessments were both ophthalmoscopic and histological.
Main Results:
- No ophthalmoscopic or histological retinal changes were detected in the treatment group.
- Control groups showed increased retinal lesions with higher laser power (up to 50%).
- Histology revealed coagulative necrosis in control groups at higher laser intensities.
Conclusions:
- Laser activation of this corneal adhesive is safe for retinal tissue.
- The clinical application of this technology in humans is unlikely to cause laser-induced retinal damage.
- Higher laser power or extended exposure durations can lead to retinal damage.
