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Dorsal Root Ganglia Isolation and Primary Culture to Study Neurotransmitter Release
Published on: October 6, 2018
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Dorsal Root Ganglion (DRG) and Chronic Pain
Amnon A Berger1, Yao Liu1, HarLee Possoit2
1Beth Israel Deaconess Medical Center, Department of Anesthesiology, Critical Care, and Pain Medicine, Harvard Medical School, Boston, MA, USA.
Anesthesiology and Pain Medicine
|August 2, 2021
Summary
Dorsal root ganglia (DRG) stimulation offers a promising approach for managing chronic neuropathic pain, a condition affecting millions. Emerging evidence suggests DRG neuromodulation effectively alleviates pain, improving quality of life.
Area of Science:
- Neurology
- Pain Management
- Neurosurgery
Background:
- Chronic neuropathic pain affects up to 11.9% of the population, causing significant morbidity and reduced quality of life.
- This condition incurs substantial healthcare costs and lost productivity.
- Dorsal root ganglia (DRG) stimulation is an emerging technique showing promise for alleviating chronic pain.
Purpose of the Study:
- To review the background, anatomical, and clinical considerations of DRG stimulation.
- To examine the clinical evidence supporting the use of DRG stimulation for chronic pain.
Main Methods:
- Review of reported cases and small randomized trials on DRG stimulation and neuromodulation.
- Exploration of the efficacy of DRG stimulation for chronic pain treatment.
- Investigation into the role of DRG glial cells and inflammatory markers in chronic pain development.
Main Results:
- Published studies, including case reports and small trials, indicate promising results for DRG stimulation.
- Evidence, though of low quality, supports the utilization of DRG stimulation techniques.
- DRG neuromodulation shows potential for effective chronic pain control.
Conclusions:
- DRG neuromodulation is an effective technique for controlling chronic neuropathic pain.
- Further large-scale randomized trials are needed to evaluate DRG modulation against other treatments.
- Future studies will inform patient selection and treatment strategies for DRG neuromodulation.
Keywords:
ACNESAscending TractsChronic PainDorsal Root GangliaInterventional Pain ManagementNeuropathyPost-herpetic NeuralgiaMore Related Videos
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