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Updated: Oct 26, 2025

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors
Published on: March 1, 2020
Epithelial Ovarian Cancer and Cancer Stem Cells
Amr A Soliman1, Alaa A Elzarkaa2, Eduard Malik3
1Universitätsklinik für Gynäkologie und Geburtshilfe, Klinikum Oldenburg AöR, Carl von Ossietzky Universität, Oldenburg, Oldenburg, Germany. amr.soliman@uni-oldenburg.de.
Abstract:
Epithelial ovarian cancer is a lethal gynecological cancer. It is related to high mortality because the majority of the patients present in advanced stage and because of the high recurrence rates of the disease. Recurrent ovarian cancer is classified according to the time interval between the last platinum-based chemotherapy and the occurrence of recurrence, to platinum-sensitive and platinum-resistant. Many theories tried to explain development of resistance to platinum-based therapy. "Cancer stem cells" is one of these theories and is being currently under investigation by many groups. This chapter will demonstrate the suggested contribution of cancer stem cells to the development of recurrent ovarian cancer.
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