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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Induced Pluripotent Stem Cells01:06

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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Related Experiment Video

Updated: Oct 25, 2025

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
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Multipotent Stromal Cells and Viral Interaction: Current Implications for Therapy.

Nopmanee Taechangam1, Amir Kol1, Boaz Arzi2

  • 1Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.

Stem Cell Reviews and Reports
|August 4, 2021
PubMed
Summary
This summary is machine-generated.

Multipotent stromal cells (MSCs) show promise in treating viral infections by suppressing viral replication and enhancing immune response. MSC therapy may balance pathogen clearance with controlling excessive immune reactions.

Keywords:
Antiviral immunityMesenchymal stem cellMultipotent stromal cellsViral diseaseVirus interaction

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Area of Science:

  • Immunology
  • Virology
  • Regenerative Medicine

Background:

  • Multipotent stromal cells (MSCs) possess immunomodulatory properties, making them valuable in various therapies.
  • The application of MSCs in treating infectious viral diseases remains an underexplored area.
  • Understanding MSCs' role in viral infections is crucial for developing novel therapeutic strategies.

Purpose of the Study:

  • To review the current applications of MSCs in virus-associated conditions.
  • To investigate MSCs' susceptibility to viral infections and their inherent antiviral properties.
  • To evaluate the impact of MSCs on cell-based immune responses and their therapeutic implementation in viral diseases.

Main Methods:

  • Literature review of current research on MSCs in viral diseases.
  • Analysis of studies detailing MSCs' interaction with viruses and the immune system.
  • Compilation of data from animal models and human clinical trials involving MSC therapy for viral infections.

Main Results:

  • MSCs demonstrate the ability to suppress viral replication.
  • MSCs enhance antiviral immunity, aiding in pathogen clearance.
  • MSC therapy shows potential in animal models and human trials for viral diseases.

Conclusions:

  • MSCs offer a novel therapeutic approach for viral infections.
  • MSC therapy can modulate the immune response, balancing pathogen clearance and preventing hyperinflammation.
  • Further research into MSCs' antiviral capabilities is warranted for clinical translation.