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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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In-Situ-Sprayed Dual-Functional Immunotherapeutic Gel for Colorectal Cancer Postsurgical Treatment.

Xinghui Si1,2, Guofeng Ji3, Sheng Ma1,2

  • 1Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.

Advanced Healthcare Materials
|August 4, 2021
PubMed
Summary
This summary is machine-generated.

A novel immunotherapeutic gel for colorectal cancer (CRC) surgery enhances antitumor immunity and prevents recurrence. This treatment combats postsurgical immunosuppression, offering a promising new therapy for CRC patients.

Keywords:
colorectal cancercontrolled releaseimmunotherapypostsurgical treatmenttumor microenvironment

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Area of Science:

  • Oncology
  • Immunotherapy
  • Biomaterials

Background:

  • Colorectal cancer (CRC) surgery can paradoxically accelerate recurrence due to postsurgical immunosuppression.
  • Modulating the tumor immune microenvironment and boosting systemic antitumor immunity are critical for effective CRC therapy.

Purpose of the Study:

  • To develop and evaluate an in-situ-sprayed immunotherapeutic gel (iSGels@aOX40) for postsurgical colorectal cancer treatment.
  • To assess the gel's ability to inhibit tumor recurrence and establish immune memory.

Main Methods:

  • An injectable hydrogel (iSGels) was formulated using tannic acid (TA) and PLG-g-mPEG/PBA, loaded with anti-OX40 antibody (aOX40).
  • TA was utilized for its crosslinking properties and ability to inhibit cyclo-oxygenase-2 (COX-2), reducing immunosuppression.
  • The sustained release of aOX40 from the gel was confirmed over 20 days.

Main Results:

  • In a subcutaneous CRC model, iSGels@aOX40 completely inhibited tumor recurrence.
  • Treated mice developed resistance to tumor re-challenge, indicating established immune memory.
  • In an orthotopic peritoneal metastasis model, iSGels@aOX40 significantly suppressed metastatic tumor growth.

Conclusions:

  • The in-situ-sprayed iSGels@aOX40 effectively combats postsurgical immunosuppression and recurrence in colorectal cancer models.
  • This approach demonstrates significant potential for improving clinical outcomes in colorectal cancer therapy.