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Updated: Oct 25, 2025

Measuring Attachment and Internalization of Influenza A Virus in A549 Cells by Flow Cytometry
Published on: November 4, 2015
Human Platelets and Influenza Virus: Internalization and Platelet Activation
Josiah Bote1, Heather A Corkrey1, Milka Koupenova1
1Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA USA.
Abstract:
Influenza infection has long been associated with prothrombotic outcomes in patients and platelets are the blood component predominantly responsible for thrombosis. In this review, we outline what is known about influenza interaction with human platelets, virion internalization, and viral RNA sensing, and the consequent impact on platelet function. We further discuss activation of platelets by IgG-influenza complexes and touch upon mechanisms of environmental platelet activation that relate to prothrombotic outcomes in patients during infection.
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