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Necroptosis, the Other Main Caspase-Independent Cell Death

Larissa C Zanetti1, Ricardo Weinlich2

  • 1Hospital Israelita Albert Einstein. Av. Albert Einstein, São Paulo, SP, Brazil. larissa.zanetti@einstein.br.

Advances in Experimental Medicine and Biology
|August 9, 2021
PubMed

Insights

Necroptosis is a distinct cell death pathway with necrotic traits, crucial for homeostasis and disease. This chapter explores its regulators, similarities with ferroptosis, and potential crosstalk.

Area of Science:

  • Cellular biology
  • Molecular mechanisms of cell death

Background:

  • Recent decades revealed novel cell death modes like ferroptosis, pyroptosis, and necroptosis.
  • These pathways share common necrotic characteristics.

Purpose of the Study:

  • To revisit early discoveries of necroptosis as a distinct cell death mechanism.
  • To describe necroptosis, its regulators, and their roles in homeostasis and disease.

Main Methods:

  • Review of early discoveries and literature on necroptosis.
  • Analysis of necroptosis regulators and their functions.
  • Comparative analysis of necroptosis and ferroptosis.

Main Results:

  • Necroptosis is a distinct cell death pathway.
  • Key regulators of necroptosis have been identified.
  • Necroptosis plays a role in cellular homeostasis and disease states.

Conclusions:

  • Necroptosis shares phenotypic similarities with ferroptosis.
  • Potential crosstalk exists between necroptosis and ferroptosis pathways.
Keywords:
InflammationMLKLNecroptosisRIPK1RIPK3TNF

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