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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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Related Experiment Video

Updated: Oct 24, 2025

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PET Imaging for Hematologic Malignancies.

Nicola M Hughes1, Heather A Jacene1

  • 1Department of Imaging and Radiology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA.

Radiologic Clinics of North America
|August 16, 2021
PubMed
Summary

Positron emission tomography/computed tomography (PET/CT) is crucial for evaluating hematologic malignancies like lymphoma and multiple myeloma. This imaging technique is increasingly important for diagnosing and monitoring these complex blood cancers.

Keywords:
Hematologic malignanciesHistiocytosisLeukemiaLymphomaMyelomaPET/CTResponse assessmentStaging

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Murine Lymphocyte Labeling by 64Cu-Antibody Receptor Targeting for In Vivo Cell Trafficking by PET/CT
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Area of Science:

  • Oncology
  • Radiology
  • Hematology

Background:

  • Hematologic malignancies encompass over 100 subtypes originating from lymphoid and myeloid cells.
  • The 2016 World Health Organization classification integrates molecular markers for diagnosis.
  • Accurate classification is essential for effective patient management.

Purpose of the Study:

  • To review the role of positron emission tomography/computed tomography (PET/CT) in evaluating specific hematologic malignancies.
  • To highlight the importance of PET/CT in diagnosing and staging lymphoma and multiple myeloma.
  • To discuss emerging indications for PET/CT in other hematologic neoplasms.

Main Methods:

  • Review of current literature and clinical guidelines on PET/CT in hematologic malignancies.
  • Focus on diagnostic and prognostic applications of PET/CT.
  • Discussion of imaging findings in common and less common hematologic cancers.

Main Results:

  • PET/CT is an integral component in the evaluation of lymphoma and multiple myeloma.
  • Imaging findings correlate with disease burden and treatment response.
  • PET/CT offers valuable insights for staging and monitoring treatment efficacy.

Conclusions:

  • PET/CT plays a vital role in the management of key hematologic malignancies.
  • Its utility extends to less common neoplasms, reflecting evolving clinical practice.
  • Continued research will further define the optimal use of PET/CT in hematologic oncology.