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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Advances and Considerations in the Management of Actinic Keratosis: An Expert Consensus Panel Report

James Del Rosso, April W Armstrong, Brian Berman

    Journal of Drugs in Dermatology : JDD
    |August 16, 2021
    PubMed
    Abstract

    Insights

    Actinic Keratosis (AK) management requires understanding treatment efficacy and patient adherence. Newer therapies for AKs may improve outcomes through faster action and shorter treatment courses, enhancing patient compliance.

    Area of Science:

    • Dermatology
    • Oncology
    • Dermatopathology

    Background:

    • Actinic Keratosis (AK) is a pre-malignant skin condition with uncertain progression risk to invasive squamous cell carcinoma (SCC).
    • Recurrent AK treatment cycles can be hindered by therapeutic efficacy and patient adherence challenges.

    Purpose of the Study:

    • To synthesize current literature on AK management into guiding principles.
    • To enhance patient experiences and treatment outcomes for Actinic Keratosis.

    Main Methods:

    • Systematic literature review on AK epidemiology, natural history, prognosis, and management.
    • Expert consensus panel (10 dermatologists/dermatopathologists) using a modified Delphi process.
    • Development and supermajority adoption of consensus statements on AK pathogenesis and management.

    Main Results:

    • Seven consensus statements on Actinic Keratosis pathogenesis and management were developed by the expert panel.

    Conclusions:

    • The undefined risk of AK progression to SCC necessitates long-term, effective treatment strategies.
    • Understanding newer AK therapies with rapid onset, shorter courses, and reduced local skin reactions is crucial for dermatologist counseling and improved patient adherence and outcomes.

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