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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Antihistamines in Psoriasis.

Swathi Shivakumar, Simon M Mueller, Paul S Yamauchi

    Journal of Drugs in Dermatology : JDD
    |August 16, 2021
    PubMed
    Summary
    This summary is machine-generated.

    Antihistamines may effectively manage itch in psoriasis, a chronic inflammatory condition. This review explores their role in reducing this common and distressing symptom.

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    Area of Science:

    • Dermatology
    • Immunology
    • Pharmacology

    Background:

    • Psoriasis is a chronic, polygenic inflammatory disease influenced by interleukin-17 (IL-17) and IL-23.
    • Itch is a prevalent and burdensome symptom in psoriasis patients.
    • Histamine's role in psoriasis itch has been historically underestimated.

    Purpose of the Study:

    • To review the efficacy of antihistamines in managing itch associated with psoriasis.
    • To evaluate the current evidence supporting the use of antihistamines for psoriasis-related pruritus.

    Main Methods:

    • A literature search was conducted using MEDLINE and PubMed databases.
    • Included peer-reviewed articles (clinical trials, scientific reviews) published in English until January 2021.
    • Reference lists of relevant articles were also reviewed.

    Main Results:

    • Evidence suggests antihistamines can be effective in reducing itch in psoriasis.
    • The review consolidates findings on antihistamine utility for psoriasis-induced pruritus.

    Conclusions:

    • Antihistamines show promise as a therapeutic option for managing itch in psoriasis.
    • Further research may clarify the specific mechanisms and optimal use of antihistamines in psoriasis management.