Accommodative amplitudes and high-order aberrations in patients with multiple sclerosis with optic nerve ınvolvement

Area of Science:

• Ophthalmology
• Neuroscience
• Optometry

Background:

• Multiple sclerosis (MS) can cause transient visual impairments.
• Understanding changes in visual function, like accommodation and corneal aberrations, is crucial for MS patient care.

Purpose of the Study:

• To investigate and compare changes in corneal aberrations and accommodative amplitudes in patients with multiple sclerosis (MS) versus normal individuals.
• To identify potential links between MS, visual function, and aberrations.

Main Methods:

• Compared 20 MS patients (with optic nerve involvement) and 20 healthy controls (under 40 years old).
• Measured accommodative amplitude using the minus lens test.
• Evaluated higher-order aberrations with the iDesign aberrometer.

Main Results:

• Accommodative amplitude was significantly lower in the MS group (4.05 D) compared to controls (6.00 D) (p<0.001).
• No significant difference was found in the root mean square of higher-order aberrations between MS patients and controls (p<0.824).
• Aberration changes during accommodation showed no significant differences between groups.

Conclusions:

• Decreased accommodative amplitude in MS patients may contribute to transient visual impairments.
• Higher-order aberration changes during accommodation are not significantly different between MS patients and controls.