Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Study Design in Statistics01:15

Study Design in Statistics

9.6K
A study design is a set of techniques that allow a researcher to collect and analyze data from different variables defined for a specific research problem. Statistics is commonly for effective study design and more robust experiments,
Does aspirin reduce the risk of heart attacks? Is one brand of fertilizer more effective at growing roses than another? Is fatigue as dangerous to a driver as the influence of alcohol? Questions like these are answered using randomized experiments with proper...
9.6K
Time-Series Graph00:54

Time-Series Graph

4.7K
A time-series graph is a line graph with repeated measurements taken at successive intervals of time. It is also called a time series chart. To construct a time-series graph, one must look at both pieces of a paired data set. The horizontal axis is used to plot the time increments, and the vertical axis is used to plot the values of the variable that one is measuring. By using the axes in this way, each point on the graph will correspond to time and a measured quantity. The points on the graph...
4.7K
Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs01:15

Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs

38
Body:Bioequivalence experimental study designs play a pivotal role in testing the effectiveness of various treatments. Key among these are the repeated measures, cross-over, carry-over, and Latin square designs. In the repeated measures design, each subject receives all treatments, allowing for temporal comparisons. This type of design is useful in reducing variability but requires careful planning to avoid bias.The cross-over design, an economical method, involves sequential administration of...
38
Experimental Designs01:16

Experimental Designs

16.0K
An experimental design is a systematic process that allows researchers to evaluate the relationship between dependent and independent variables. There are three widely used types of experimental design - pre-experimental design, true experimental design, and quasi-experimental design. In pre-experimental design, the researcher compares the data before and after some interventions or treatments. The true-experimental design has more than one purposefully created group, a commonly measured...
16.0K
Introduction To Survival Analysis01:18

Introduction To Survival Analysis

443
Survival analysis is a statistical method used to study time-to-event data, where the "event" might represent outcomes like death, disease relapse, system failure, or recovery. A unique feature of survival data is censoring, which occurs when the event of interest has not been observed for some individuals during the study period. This requires specialized techniques to handle incomplete data effectively.
The primary goal of survival analysis is to estimate survival time—the time...
443
Case Studies01:22

Case Studies

12.8K
There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.
12.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Extreme heat and cause-specific risk of hospital admission in the adult population in England: a case time series analysis.

BMJ open·2026
Same author

Interaction Between Air Pollution and Genetic Predisposition to Blood Pressure and LDL-C on Cardiovascular Events.

European journal of preventive cardiology·2026
Same author

Minimum mortality temperature by cause of death and age group: A multi-country observational study (1990-2019).

Environmental research·2026
Same author

Temporal changes in mortality risk associated with PM<sub>10</sub> across 143 cities in 26 countries: a multicountry, multicity time-series study.

The Lancet. Planetary health·2026
Same author

Projecting climate change impacts on health: A tutorial integrating the latest climate and demographic scenarios.

Environmental epidemiology (Philadelphia, Pa.)·2026
Same author

The burden of premature births attributed to heat across 13 countries.

Environment international·2026
Same journal

Can the All of Us sample be reweighted to mirror a nationally representative sample? A comparison of mortality predictors.

Epidemiology (Cambridge, Mass.)·2026
Same journal

Gut health, systemic inflammation, and linear growth among Indonesian infants: findings from the Action Against Stunting Hub observation cohort: Erratum.

Epidemiology (Cambridge, Mass.)·2026
Same journal

Evaluating Estimators in Partially Identified Models.

Epidemiology (Cambridge, Mass.)·2026
Same journal

Stratification and accumulation? Explaining changing mortality inequities between business owners and non-owners in the U.S. (1984-2022).

Epidemiology (Cambridge, Mass.)·2026
Same journal

Be wary of age-stratum aging in early-onset cancer trends.

Epidemiology (Cambridge, Mass.)·2026
Same journal

The Authors Respond.

Epidemiology (Cambridge, Mass.)·2026
See all related articles

Related Experiment Video

Updated: Oct 23, 2025

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study
20:24

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study

Published on: January 31, 2014

16.7K

The Case Time Series Design.

Antonio Gasparrini1,2

  • 1Department of Public Health Environments and Society, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Epidemiology (Cambridge, Mass.)
|August 25, 2021
PubMed
Summary
This summary is machine-generated.

A new case time series design enables epidemiologic studies on transient health risks. This method uses linked data to analyze time-varying exposures and health outcomes effectively.

More Related Videos

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
09:05

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Published on: October 17, 2025

16
A Cross-Disciplinary and Multi-Modal Experimental Design for Studying Near-Real-Time Authentic Examination Experiences
08:33

A Cross-Disciplinary and Multi-Modal Experimental Design for Studying Near-Real-Time Authentic Examination Experiences

Published on: September 4, 2019

7.2K

Related Experiment Videos

Last Updated: Oct 23, 2025

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study
20:24

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study

Published on: January 31, 2014

16.7K
Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
09:05

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Published on: October 17, 2025

16
A Cross-Disciplinary and Multi-Modal Experimental Design for Studying Near-Real-Time Authentic Examination Experiences
08:33

A Cross-Disciplinary and Multi-Modal Experimental Design for Studying Near-Real-Time Authentic Examination Experiences

Published on: September 4, 2019

7.2K

Area of Science:

  • Epidemiology
  • Biostatistics
  • Data Science

Background:

  • Modern data linkage and technologies enable detailed longitudinal health profiles.
  • Rich data resources present opportunities for novel epidemiologic investigations.
  • Traditional study designs are often insufficient for analyzing complex, time-varying exposures.

Purpose of the Study:

  • Introduce a new study design, case time series, for investigating transient health risks.
  • Address the need for innovative analytical approaches with modern longitudinal data.
  • Develop a flexible and efficient methodology for epidemiologic research.

Main Methods:

  • The case time series design combines longitudinal structure with individual-level analysis.
  • It allows flexible control of time-varying confounders and time-invariant differences.
  • The modeling framework is adaptable and uses efficient estimation and computational methods.

Main Results:

  • A simulation study demonstrated the methodology's validity across various data settings.
  • Case studies successfully replicated analyses on influenza and myocardial infarction risk.
  • The design was illustrated using real-time smartphone data on environmental exposures and respiratory symptoms.

Conclusions:

  • The case time series design is a general and flexible tool for epidemiologic research.
  • It is applicable to transient associations with environmental factors, clinical conditions, or medications.
  • This approach is suitable for analyzing highly informative longitudinal data resources.