Related Experiment Video

Updated: Oct 22, 2025

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4
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A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

Published on: March 10, 2018

14.0K

Coxsackievirus and Adenovirus Receptor (CXADR): Recent Findings and Its Role and Regulation in Spermatogenesis

Yang Zhang1, Wing-Yee Lui2

  • 1School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong.

Advances in Experimental Medicine and Biology
|August 28, 2021
PubMed

Insights

The Coxsackievirus and adenovirus receptor (CXADR) is vital for cell adhesion and signaling, with crucial roles in the heart and testis. This review highlights CXADR

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Reproductive Biology

Background:

  • The Coxsackievirus and adenovirus receptor (CXADR), a member of the immunoglobulin superfamily, is expressed broadly.
  • CXADR plays critical roles in specialized tissues like the heart and testis.
  • It functions as a viral receptor, structural protein, and signaling molecule.

Purpose of the Study:

  • To review the multifaceted roles of CXADR.
  • To emphasize recent findings concerning CXADR in spermatogenesis.
  • To guide future research on CXADR's function and regulation in the testis.

Main Methods:

  • Literature review of existing studies on CXADR.
  • Analysis of CXADR's functions including viral binding, cell adhesion, and signaling.
  • Focus on experimental evidence related to testicular functions.

Main Results:

  • CXADR facilitates leukocyte transmigration and regulates barrier function.
  • It is involved in cell adhesion, epithelial-mesenchymal transition (EMT), and spermatogenesis.
  • Unique indispensable functions of CXADR are noted in the heart and testis.

Conclusions:

  • CXADR is a multifunctional protein with significant roles in various physiological processes.
  • Its indispensable functions in the testis highlight its importance in spermatogenesis.
  • Further research is needed to fully elucidate CXADR's roles and regulatory mechanisms in male reproduction.
Keywords:
Cell junctionCoxsackievirus and adenovirus receptor (CXADR)SignallingSpermatogenesisViral receptor

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