EFFICACY OF RADIOSURGERY IN TREATMENT OF MALIGNANT TUMOR OF LARYNX

The aim of the work was to evaluate the effectiveness of the radiosurgery method in the treatment of malignant tumors of the larynx. The treatment of 48 patients was carried out using the "Rocus-AM" device. The larynx was irradiated 5 times a week, with a single focal dose of 2.5 Gy and a total dose of 35 Gy. Besides the radiotherapy, the patients received intravenous 5-fluorouracil in a dose of 250 mg/m2 every other day during the whole course of the radiotherapy. After 14 days, the tumour response to irradiation was assessed. The clinical monitoring of the course of the disease has resulted in 1) recovery of laryngeal dividing function within two days in 100% of patients; 2) temporary swallowing dysfunction in 8% of patients, and 3) recovery of respiratory function at 2-6 months after therapy in 98% of patients. The three-year recurrence-free survival rate was 95.8%. The prospects for further research and improvement of the technique are related to the necessity of a comparative analysis of the recurrence-free survival of patients with laryngeal cancer treated with this technique and control groups of patients who received presurgical or postsurgical distant radiotherapy.