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Compression of the optic chiasm due to a lymphoreticular malignancy
R S Howard1, A S Duncombe, C Owens
1Department of Medical Ophthalmology, St. Thomas' Hospital, London, UK.
Postgraduate Medical Journal
|December 1, 1987
Summary
Chronic lymphocytic leukemia (CLL) can present as a primary intracranial infiltration, causing visual loss. This case is the first report of a chiasmal syndrome due to CLL without other lymphoreticular involvement.
Area of Science:
- Neurology
- Hematology
- Ophthalmology
Background:
- Chronic lymphocytic leukemia (CLL) is a common lymphoproliferative disorder.
- Intracranial involvement in CLL is rare, especially as an initial presentation.
Observation:
- A patient presented with significant visual loss.
- The cause was identified as infiltration of the optic chiasm.
Findings:
- The optic chiasm infiltration was due to chronic lymphocytic leukemia.
- This represented a primary intracranial manifestation of CLL.
- No other lymphoreticular involvement was detected.
Implications:
- This case highlights the potential for atypical presentations of CLL.
- Optic chiasm infiltration by CLL can lead to visual impairment.
- It underscores the importance of considering hematologic malignancies in neurological presentations.