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Updated: Oct 19, 2025

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
Published on: September 20, 2017
Calculation of Aqueous Solubility of Organic Compounds
Yadu B Tewari1, Michele M Miller1, Stanley P Wasik1
1National Bureau of Standards, Washington, DC 20234.
Abstract:
The aqueous solubility of 14 organic solutes has been calculated from their octanol/water partition coefficient and from their solute activity coefficient in octanol at infinite dilution. The solute activity coefficients were calculated from the Flory-Huggins and Hildebrand-Scatchard (FH-HS) equations and were found to be in good agreement with the activity coefficients determined from GC specific retention volume measurements. The calculated solubilities were in good agreement with the experimental solubilities.
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