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Production and Preparation of Porcine Urinary Bladder Matrix (UBM) for Urinary Bladder Tissue-Engineering Purposes
1Department of Surgery, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland. nialldavis@rcsi.ie.
Advances in Experimental Medicine and Biology
|September 28, 2021
Summary
Gastrointestinal tissue repair for end-stage bladder disease causes lifelong complications. Porcine urinary bladder matrix (UBM) offers a promising alternative for bladder regeneration, potentially mitigating these issues.
Area of Science:
- Regenerative Medicine
- Urology
- Biomaterials Science
Background:
- Current surgical repair for end-stage bladder disease uses gastrointestinal tissue, leading to frequent, lifelong complications.
- These complications include metabolic and neuromechanical issues, affecting nearly all patients undergoing such procedures.
Purpose of the Study:
- To describe the production and preparation techniques for porcine urinary bladder matrix (UBM).
- To evaluate porcine UBM as a potential alternative for bladder tissue engineering and regenerative purposes.
Main Methods:
- Utilizing decellularized, biocompatible, and biodegradable extracellular matrix (ECM) derived from porcine urinary bladders.
- Focusing on techniques for preparing porcine UBM for regenerative applications in urology.
Main Results:
- Porcine UBM is a tissue-engineered biomaterial derived from animal extracellular matrix.
- This biomaterial is biocompatible and biodegradable, suitable for regenerative medicine.
Conclusions:
- Porcine UBM presents a viable alternative to traditional gastrointestinal tissue grafts for bladder repair.
- The preparation techniques discussed aim to facilitate bladder regeneration and mitigate post-operative complications.
